Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human heart with TNFRSF11A monoclonal antibody, clone 9A725 (Cat # MAB12970) at 10 ug/mL working concentration.
Flow cytometric analysis of 106 RAW 264.7 cells with TNFRSF11A monoclonal antibody, clone 9A725 (Cat # MAB12970) at 2 ug/mL working concentration represented by red histogram, an isotype control represented by green histogram and no antibody present represented by shaded histogram.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Studies of the mouse counterpart suggest that this receptor directly mediates the osteoprotegerin ligand (OPGL)-induced osteoclastogenesis in osteoclast precursor cells. [provided by RefSeq
loss of heterozygosity, 18, chromosomal region 1,osteoclast differentiation factor receptor,receptor activator of nuclear factor-kappa B,tumor necrosis factor receptor superfamily, member 11a,tumor necrosis factor receptor superfamily, member 11a, activat