GYPA/GYPB monoclonal antibody, clone HIR2
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More Files
- More Functions
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney, red blood cells with GYPA/GYPB monoclonal antibody, clone HIR2 (Cat # MAB12957) at 1:50 dilution.
Flow Cytometry
Flow cytometric analysis of human red blood cells with GYPA/GYPB monoclonal antibody, clone HIR2 (Cat # MAB12957).
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Specification
Product Description
Mouse monoclonal antibody raised against human GYPA/GYPB.
Immunogen
Human peripheral blood mononuclear cell (PBMC).
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Isotype
IgG2b
Recommend Usage
Flow Cytometry
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (0.09% sodium azide).
Storage Instruction
Store at 4°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney, red blood cells with GYPA/GYPB monoclonal antibody, clone HIR2 (Cat # MAB12957) at 1:50 dilution.Flow Cytometry
Flow cytometric analysis of human red blood cells with GYPA/GYPB monoclonal antibody, clone HIR2 (Cat # MAB12957). -
Gene Info — GYPA
Entrez GeneID
2993Gene Name
GYPA
Gene Alias
CD235a, GPA, GPErik, GPSAT, GpMiIII, HGpMiIII, HGpMiV, HGpMiX, HGpMiXI, HGpSta(C), MN, MNS
Gene Description
glycophorin A (MNS blood group)
Gene Ontology
HyperlinkGene Summary
Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. In addition to the M or N and S or s antigens that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta, as well as Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. [provided by RefSeq
Other Designations
Mi.V glycoprotein (24 AA)|erythroid-lineage-specific membrane sialoglycoprotein|glycophorin A|glycophorin A (MN blood group)|glycophorin A MNS blood group|glycophorin A, GPA|glycophorin Erik|glycophorin MiI|glycophorin MiIII|glycophorin MiV|glycophorin Mi
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Gene Info — GYPB
Entrez GeneID
2994Gene Name
GYPB
Gene Alias
CD235b, GPB, GPB.NY, GYPHe.NY, HGpMiVI, MNS, SS
Gene Description
glycophorin B (MNS blood group)
Omim ID
111740Gene Ontology
HyperlinkGene Summary
Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. GYPB gene consists of 5 exons and has 97% sequence homology with GYPA from the 5' UTR to the coding sequence encoding the first 45 amino acids. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. [provided by RefSeq
Other Designations
Ss blood group|glycophorin B|glycophorin HeP2|glycophorin MiVI
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Interactome
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Pathway
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Disease
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