ATM monoclonal antibody, clone 3E8
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Specifications
Product Description
Mouse monoclonal antibody raised against partial recombinant human ATM.
Immunogen
Recombinant protein corresponding to amino acids 980-1512 of human ATM.
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Isotype
IgG1
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (5 ug/mL)
Immunoprecipitation
Western Blot
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4.
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney with ATM monoclonal antibody, clone 3E8 (Cat # MAB12914) at 5 ug/mL working concentration.Immunoprecipitation
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Gene Info — ATM
Entrez GeneID
472Protein Accession#
Q13315Gene Name
ATM
Gene Alias
AT1, ATA, ATC, ATD, ATDC, ATE, DKFZp781A0353, MGC74674, TEL1, TELO1
Gene Description
ataxia telangiectasia mutated
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
AT mutated|TEL1, telomere maintenance 1, homolog|ataxia telangiectasia mutated (includes complementation groups A, C and D)|ataxia telangiectasia mutated protein|human phosphatidylinositol 3-kinase homolog|serine-protein kinase ATM
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Interactomes
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Pathways
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Diseases
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