Western Blot analysis of Lane 1: Jurkat nuclear cell extracts and Lane 2: NIH/3T3 nuclear extracts with WDHD1 monoclonal antibody, clone 20G10 (Cat # MAB12908) followed by HRP-conjugated goat anti-mouse IgG secondary antibody and visualized by chemiluminescence detection system.
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human tonsil (A) and human colon (B) with WDHD1 monoclonal antibody, clone 20G10 (Cat # MAB12908) at 15 ug/mL working concentration.
The protein encoded by this gene contains multiple N-terminal WD40 domains and a C-terminal high mobility group (HMG) box. WD40 domains are found in a variety of eukaryotic proteins and may function as adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq