Mouse monoclonal antibody raised against human KRT8/KRT18.
Immunogen:
Human breast cancer PMC42 cells.
Host:
Mouse
Reactivity:
Human
Form:
Liquid
Conjugation:
FITC
Purification:
Protein A purification
Isotype:
IgG1, kappa
Recommend Usage:
Flow Cytometry (2-10 ug/mL) Immunocytochemistry (10-20 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50) The optimal working dilution should be determined by the end user.
Storage Buffer:
In PBS, pH 7.4 (1% BSA, 0.05% sodium azide).
Storage Instruction:
Store at 4°C. Aliquot to avoid repeated freezing and thawing.
Note:
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human liver with KRT8/KRT18 monoclonal antibody, clone CK 209 (FITC) (Cat # MAB12882).
This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. [provided by RefSeq
KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
Other Designations:
cell proliferation-inducing protein 46,cytokeratin 18