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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunocytochemistry

Flow Cytometry

Entrez GeneID

Gene Name

KRT8

Gene Alias

CARD2, CK8, CYK8, K2C8, K8, KO

Gene Description

keratin 8

Omim ID

Gene Ontology

Gene Summary

This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. [provided by RefSeq

Other Designations

cytokeratin 8|keratin, type II cytoskeletal 8

Entrez GeneID

Gene Name

KRT18

Gene Alias

CYK18, K18

Gene Description

keratin 18

Omim ID

Gene Ontology

Gene Summary

KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq

Other Designations

cell proliferation-inducing protein 46|cytokeratin 18