Western Blot analysis of Lane 1: HepG2 (human), Lane 2: HeLa (human), Lane 3: SVT2 (mouse), Lane 4: A549 (human), Lane 5: COS7 (monkey), Lane 6: Jurkat (human), Lane 7: MDCK (dog), Lane 8: PC12 (rat) and Lane 9: MCF7 (human) (35 ug/lane) with DPP9 monoclonal antibody, clone 6A12 (Cat # MAB12862).
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney with DPP9 monoclonal antibody, clone 6A12 (Cat # MAB12862) at 10 ug/mL working concentration.
Flow cytometric analysis of HEK 293T cells transfected with either overexpress plasmid (Red) or empty vector control plasmid (Blue) using DPP9 monoclonal antibody, clone 6A12 (Cat # MAB12862) (A) and Jurkat cells using DPP9 monoclonal antibody, clone 6A12 (Cat # MAB12862) (Red) compared to a nonspecific negative control antibody (Blue) (B).
This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. The protein has been shown to have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Although the activity of this protein is similar to that of dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane bound. In general, dipeptidyl peptidases appear to be involved in the regulation of the activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. Several transcript variants of this gene have been described but not fully characterized. [provided by RefSeq