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Last updated: 2017/12/17

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MMP14 monoclonal antibody, clone 133CT15.10.5.1

  • Catalog # : MAB12762
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against synthetic peptide of human MMP14.
  • Immunogen:
  • A synthetic peptide (conjugated with KLH) corresponding to amino acids 470-499 at C-terminus region of human MMP14.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Euglobin precipitation
  • Isotype:
  • IgM
  • Recommend Usage:
  • Immunofluorescence (1:10 - 1:50)
    Western Blot (1:100 - 1:500)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.09% sodium azide).
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate) analysis of A2058 cell lysate (35 ug) with MMP14 monoclonal antibody, clone 133CT15.10.5.1 (Cat # MAB12762).
  • Immunofluorescence
  • Immunofluorescence
  • Immunofluorescent staining of HepG2 cell with MMP14 monoclonal antibody, clone 133CT15.10.5.1 (Cat # MAB12762) followed by Alexa Fluor 488-conjugated goat anti-mouse lgG (green). DAPI was used to stain the cell nuclear (blue).
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 4323
  • Gene Name:
  • MMP14
  • Gene Alias:
  • MMP-X1,MT1-MMP,MTMMP1
  • Gene Description:
  • matrix metallopeptidase 14 (membrane-inserted)
  • Gene Summary:
  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq
  • Other Designations:
  • matrix metalloproteinase 14,matrix metalloproteinase 14 (membrane-inserted),membrane type 1 metalloprotease,membrane-type matrix metalloproteinase 1,membrane-type-1 matrix metalloproteinase
  • Gene Pathway
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