Western Blot (Cell lysate) analysis of A2058 cell lysate (35 ug) with MMP14 monoclonal antibody, clone 133CT18.104.22.168 (Cat # MAB12762).
Immunofluorescent staining of HepG2 cell with MMP14 monoclonal antibody, clone 133CT22.214.171.124 (Cat # MAB12762) followed by Alexa Fluor 488-conjugated goat anti-mouse lgG (green). DAPI was used to stain the cell nuclear (blue).
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq