Western blot analysis of HepG2 cell lysate with APOA1 monoclonal antibody, clone AT1E12 (Cat # MAB12761) at Lane 1: 1:500 dilution, Lane 2: 1:1000 dilution and Lane 3: 1:5000 dilution followed by HRP-conjugated goat anti-mouse secondary antibody and visualized by ECL detection system.
This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. [provided by RefSeq