NANS monoclonal antibody, clone AT1G6
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against human NANS.
Immunogen
Recombinant protein corresponding to amino acids 1-359 of human NANS.
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Isotype
IgG1, kappa
Recommend Usage
ELISA
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (10 ug/mL)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.09% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of HeLa cell lysate with NANS monoclonal antibody, clone AT1G6 (Cat # MAB12760) at Lane 1: 1:100 dilution, Lane 2: 1:1000 dilution and Lane 3: 1:3000 dilution followed by HRP-conjugated goat anti-mouse secondary antibody and visualized by ECL detection system.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human pancreas with NANS monoclonal antibody, clone AT1G6 (Cat # MAB12760).Enzyme-linked Immunoabsorbent Assay
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Gene Info — NANS
Entrez GeneID
54187Gene Name
NANS
Gene Alias
SAS
Gene Description
N-acetylneuraminic acid synthase
Omim ID
605202Gene Ontology
HyperlinkGene Summary
This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively; however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant. [provided by RefSeq
Other Designations
N-acetylneuraminic acid phosphate synthase|OTTHUMP00000021769|sialic acid phosphate synthase|sialic acid synthase
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Interactome
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Pathway
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