Products

Western Blot (Cell lysate)

Western blot analysis of HeLa cell lysate with NANS monoclonal antibody, clone AT1G6 (Cat # MAB12760) at Lane 1: 1:100 dilution, Lane 2: 1:1000 dilution and Lane 3: 1:3000 dilution followed by HRP-conjugated goat anti-mouse secondary antibody and visualized by ECL detection system.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human pancreas with NANS monoclonal antibody, clone AT1G6 (Cat # MAB12760).

Enzyme-linked Immunoabsorbent Assay

Entrez GeneID

54187

Gene Name

NANS

Gene Alias

SAS

Gene Description

N-acetylneuraminic acid synthase

Omim ID

605202

Gene Ontology

Hyperlink

Gene Summary

This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively; however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant. [provided by RefSeq

Other Designations

N-acetylneuraminic acid phosphate synthase|OTTHUMP00000021769|sialic acid phosphate synthase|sialic acid synthase