Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human lung with TLR9 monoclonal antibody, clone 72-1665 (Cat # MAB12707) at 20 ug/mL working concentration.
Flow cytometric analysis of HEK 293 parent cells (top histogram) and hTLR9 transfected cells (bottom histogram) with either anti-rat IgG-FITC alone (thin line) or TLR9 monoclonal antibody, clone 72-1665 (Cat # MAB12707) (thick line) followed by FITC-conjugated anti-rat IgG as the secondary antibody.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response. [provided by RefSeq