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IL12B monoclonal antibody, clone C8.6

  • Catalog # : MAB12705
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against human IL12B.
  • Immunogen:
  • Huamn IL12B
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Affinity purification
  • Isotype:
  • IgG1, kappa
  • Recommend Usage:
  • Flow Cytometry
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (20-40 ug/mL)
    Western Blot
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, 150 mM NaCl, pH 7.2 (0.09% sodium azide).
  • Storage Instruction:
  • Store at 4°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human thymus with IL12B monoclonal antibody, clone C8.6 (Cat # MAB12705) at 20-40 ug/mL working concentration.
  • Flow Cytometry
  • Application Image
  • Western Blot
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 3593
  • Gene Name:
  • IL12B
  • Gene Alias:
  • CLMF,CLMF2,IL-12B,NKSF,NKSF2
  • Gene Description:
  • interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
  • Gene Summary:
  • This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq
  • Other Designations:
  • IL12, subunit p40,OTTHUMP00000160820,cytotoxic lymphocyte maturation factor 2, p40,interleukin 12, p40,interleukin 12B,interleukin-12 beta chain,natural killer cell stimulatory factor, 40 kD subunit,natural killer cell stimulatory factor-2
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