Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human tonsil with TLR2 monoclonal antibody, clone 1030A5.138 (Cat # MAB12658) at 20 ug/mL working concentration.
Flow cytometric analysis of 106 human monocyte with TLR2 monoclonal antibody, clone 1030A5.138 (Cat # MAB12658) (red histogram), an isotype control (green histogram) and no antibody present (shaded histogram) followed by PE-conjugated goat anti-mouse IgG1 as the secondary antibody.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. [provided by RefSeq