Western blot analysis of Lane 1: normal peripheral human blood cells, Lane 2: Jurkat cell lysate and Lane 3: C57BL/6 splenocytes cell lysate with LAT monoclonal antibody, clone LAT.10-17 (10-17) (Cat # MAB12621).
The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq