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FCER1A monoclonal antibody, clone AER-37 (CRA1)

  • Catalog # : MAB12619
  • Visit Frequency :
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against human FCER1A.
  • Immunogen:
  • Human FCER1A
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Affinity purification
  • Isotype:
  • IgG2b, kappa
  • Recommend Usage:
  • Flow Cytometry
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (20 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, 150 mM NaCl, pH 7.2 (0.09% sodium azide).
  • Storage Instruction:
  • Store at 4°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human small intestine with FCER1A monoclonal antibody, clone AER-37 (CRA1) (Cat # MAB12619) at 20 ug/mL working concentration.
  • Flow Cytometry
  • Flow Cytometry
  • Flow cytometric analysis of human lysed whole blood with FCER1A monoclonal antibody, clone AER-37 (CRA1) (Cat # MAB12619) (blue histogram) and an isotype control mouse IgG2b (green histogram) followed by biotin-conjugated anti-mouse IgG secondary antibody and PE-conjugated streptavidin.
  • Application Image
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 2205
  • Gene Name:
  • FCER1A
  • Gene Alias:
  • FCE1A,FcERI
  • Gene Description:
  • Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
  • Gene Summary:
  • The IgE receptor plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma. The allergic response occurs when 2 or more high-affinity IgE receptors are crosslinked via IgE molecules that in turn are bound to an allergen (antigen) molecule. A perturbation occurs that brings about the release of histamine and proteases from the granules in the cytoplasm of the mast cell and leads to the synthesis of prostaglandins and leukotrienes--potent effectors of the hypersensitivity response. The IgE receptor consists of 3 subunits: alpha, beta (MIM 147138), and gamma (MIM 147139); only the alpha subunit is glycosylated.[supplied by OMIM
  • Other Designations:
  • Fc IgE receptor, alpha polypeptide,Fc epsilon RI alpha-chain,Fc-epsilon RI-alpha,high affinity immunoglobulin epsilon receptor alpha-subunit,immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide
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