Western blot analysis of Lane 1: truncated Trx-MPO recombinant protein, Lane 2: truncated MBP-MPO (amino acids 1-193) recombinant protein and Lane 3: truncated MPO (amino acids 165-745)-hIgGFc transfected CHO-K1 cell lysate with ERBB3 monoclonal antibody, clone 3F10F6 (Cat # MAB12611).
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils. [provided by RefSeq