UMOD monoclonal antibody, clone 10.32 (FITC)
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More Files
- More Functions
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney with UMOD monoclonal antibody, clone 10.32 (FITC) (Cat # MAB12564) at 1:50 dilution.
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Specification
Product Description
Mouse monoclonal antibody raised against human UMOD.
Immunogen
Human UMOD
Host
Mouse
Reactivity
Human
Form
Liquid
Conjugation
FITC
Purification
Protein G purification
Isotype
IgG2b
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (EIA grade BSA, 0.02% sodium azide).
Storage Instruction
Store in the dark at 4°C. For long term storage store at -80°C. Avoid prolonged exposure to light.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney with UMOD monoclonal antibody, clone 10.32 (FITC) (Cat # MAB12564) at 1:50 dilution. -
Gene Info — UMOD
Entrez GeneID
7369Gene Name
UMOD
Gene Alias
ADMCKD2, FJHN, HNFJ, MCKD2, THGP, THP
Gene Description
uromodulin
Gene Ontology
HyperlinkGene Summary
This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq
Other Designations
OTTHUMP00000162212|Tamm-Horsfall glycoprotein|uromodulin (uromucoid, Tamm-Horsfall glycoprotein)|uromucoid
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Interactome
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Disease
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