Mouse monoclonal antibody raised against partial recombinant human BMPR1A.
Recombinant protein corresponding to amino acids 179-378 of human BMPR1A.
ELISA (1:10000) Flow Cytometry (1:200-1:400) Immunocytochemistry (1:200-1:1000) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50) Western Blot (1:500-1:2000) The optimal working dilution should be determined by the end user.
In ascites (0.03% sodium azide)
Store at 4°C. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing.
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Western blot analysis of Lane 1: HEK293T cell lysate, Lane 2: BMPR1A (a.a.: 179-378)-hIgGFc transfected HEK293T cell lysate using BMPR1A monoclonal antibody, clone 4B7B2 (Cat # MAB12496) at 1:500-1:2000 dilution.
The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq
OTTHUMP00000020014,activin A receptor, type II-like kinase 3