Immunohistochemical staining (Frozen sections) of human spleen tissue (A), human kidney tissue (B) and human heart tissue (C) using HSPG2 monoclonal antibody, clone A7L6 (Cat # MAB12489) at 1:50 dilution.
Heparan sulfate proteoglycan is a major component of basement membranes, where the molecule may be involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion. This form of HSPG, known as HSPG2 or perlecan, is encoded by a gene that maps to chromosome 1. The gene for the form of HSPG associated with the cell surface of fibroblasts has been mapped to human chromosome 8 (MIM 142460).[supplied by OMIM
OTTHUMP00000002765,Schwartz-Jampel syndrome 1 (chondrodystrophic myotonia),endorepellin (domain V region),heparan sulfate proteoglycan of basement membrane,perlecan proteoglycan