HEXA monoclonal antibody, clone AT20F1
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of MCF7 cell lysate using HEXA monoclonal antibody, clone AT20F1 (Cat # MAB12474) at 1:3000 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human lung tissue with HEXA monoclonal antibody, clone AT20F1 (Cat # MAB12474) under 10 ug/mL working concentration.
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human HEXA.
Immunogen
Recombinant protein corresponding to amino acids 89-529 of human HEXA.
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Isotype
IgG2a, lambda
Recommend Usage
ELISA
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (10 ug/mL)
Western Blot (1:3000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (10% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of MCF7 cell lysate using HEXA monoclonal antibody, clone AT20F1 (Cat # MAB12474) at 1:3000 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human lung tissue with HEXA monoclonal antibody, clone AT20F1 (Cat # MAB12474) under 10 ug/mL working concentration.Enzyme-linked Immunoabsorbent Assay
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Gene Info — HEXA
Entrez GeneID
3073Protein Accession#
P06865Gene Name
HEXA
Gene Alias
MGC99608, TSD
Gene Description
hexosaminidase A (alpha polypeptide)
Gene Ontology
HyperlinkGene Summary
This gene encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I). [provided by RefSeq
Other Designations
GM2 gangliosidosis|N-acetyl-beta-glucosaminidase|Tay Sachs disease|beta-N-acetylhexosaminidase|hexosaminidase A
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Interactome
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Pathway
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Disease
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