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Troponin T monoclonal antibody, clone JLT-12

  • Catalog # : MAB12454
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against full length native of rabbit troponin T.
  • Immunogen:
  • Native purified troponin T from rabbit skeletal muscle.
  • Host:
  • Mouse
  • Reactivity:
  • Chicken, Rabbit, Rat
  • Form:
  • Lyophilized
  • Isotype:
  • IgG1
  • Recommend Usage:
  • Immunohistochemistry (4-8 ug/mL)
    Western Blot (2-4 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • Lyophilized from ascites fluid (1.2 % sodium acetate, 2 mg BSA, 0.01 mg sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    After reconstitution with 1 mL of 1.2% sodium acetate or neutral PBS and concentration will be 100 ug/mL, store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical staining of rat skeletal muscle tissue with Troponin T monoclonal antibody, clone JLT-12 (Cat# MAB12454) under 4-8 ug/mL working concentration.
  • Immunohistochemistry (Frozen sections)
  • Application Image
  • Western Blot
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Immunohistochemistry (Frozen sections)
  • Gene Information
  • Entrez GeneID:
  • 7138
  • Gene Name:
  • TNNT1
  • Gene Alias:
  • ANM,FLJ98147,MGC104241,STNT,TNT,TNTS
  • Gene Description:
  • troponin T type 1 (skeletal, slow)
  • Gene Summary:
  • This gene encodes a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • slow skeletal muscle troponin T,troponin T1, skeletal, slow,troponin-T1, skeletal, slow
  • Gene Information
  • Entrez GeneID:
  • 7139
  • Gene Name:
  • TNNT2
  • Gene Alias:
  • CMH2,CMPD2,MGC3889,RCM3,TnTC,cTnT
  • Gene Description:
  • troponin T type 2 (cardiac)
  • Gene Summary:
  • The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000033864,OTTHUMP00000033867,cardiomyopathy, dilated 1D (autosomal dominant),cardiomyopathy, hypertrophic 2,troponin T type 2, cardiac,troponin T, cardiac muscle,troponin T2, cardiac
  • Gene Information
  • Entrez GeneID:
  • 7140
  • Gene Name:
  • TNNT3
  • Gene Alias:
  • AMCD2B,DA2B,DKFZp779M2348,FSSV
  • Gene Description:
  • troponin T type 3 (skeletal, fast)
  • Other Designations:
  • OTTHUMP00000014433,OTTHUMP00000014434,OTTHUMP00000014435,troponin T3, skeletal, fast,troponin-T3, skeletal, fast
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