PPARA monoclonal antibody, clone 1331CT894.186.143
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Specification
Product Description
Mouse monoclonal antibody raised against human PPARA.
Immunogen
Recombinant protein corresponding to human PPARA.
Host
Mouse
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (1:25)
Immunohistochemistry (1:25)
Immunofluorescence (1:25)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of Lane 1: Hela cell line lysates Lane 2: Jurkat cell line lysates Lane 3: mouse NIH/3T3 cell line lysates reacted with PPARA monoclonal antibody (Cat # MAB12349) at 1:1000 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of paraffin-embedded human skeletal muscle section reacted with PPARA monoclonal antibody (Cat # MAB12349) at 1:25 dilution.Immunofluorescence
Immunofluorescent staining of Hela cells reacted with PPARA monoclonal antibody (Cat # MAB12349) at 1:25 dilution.Flow Cytometry
Flow cytometric analysis of Hela cells (green histogram) and an isotype control of mouse IgG1 (blue histogram) reacted with PPARA monoclonal antibody (Cat # MAB12349) at 1:25 dilution. -
Gene Info — PPARA
Entrez GeneID
5465Gene Name
PPARA
Gene Alias
MGC2237, MGC2452, NR1C1, PPAR, hPPAR
Gene Description
peroxisome proliferator-activated receptor alpha
Omim ID
170998Gene Ontology
HyperlinkGene Summary
Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq
Other Designations
OTTHUMP00000028713|OTTHUMP00000042872|peroxisome proliferative activated receptor, alpha|peroxisome proliferator activated receptor alpha
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Interactome
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Pathway
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Disease
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Publication Reference
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Alteration of CYP4A11 expression in renal cell carcinoma: diagnostic and prognostic implications.
Sup Kim, Jin Man Kim, Hyo Jin Lee, Jae Sung Lim, In-Ock Seong, Kyung-Hee Kim.
Journal of Cancer 2020 Jan; 11(6):1478.
Application:IHC, Human, Clear-cell renal cell carcinoma (ccRCC), kidney cortex, papillary renal cell carcinoma.
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Alteration of CYP4A11 expression in renal cell carcinoma: diagnostic and prognostic implications.
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