PHB monoclonal antibody, clone 1215CT487.109.106
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Specification
Product Description
Mouse monoclonal antibody raised against human PHB.
Immunogen
Recombinant protein corresponding to amino acids 1-205 of human PHB.
Host
Mouse
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Protein G purification
Isotype
IgG2b, kappa
Recommend Usage
Immunohistochemistry (1:25)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of Lane 1: 293 cell line lysates Lane 2: MCF-7 cell line lysates Lane 3: HepG2 cell line lysates Lane 4: mouse NIH/3T3 cell line lysates Lane 5: rat liver tissue lysates reacted with PHB monoclonal antibody (Cat # MAB12344) at 1:1000 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of paraffin-embedded human stomach section reacted with PHB monoclonal antibody (Cat # MAB12344) at 1:25 dilution. -
Gene Info — PHB
Entrez GeneID
5245Gene Name
PHB
Gene Alias
PHB1
Gene Description
prohibitin
Omim ID
176705Gene Ontology
HyperlinkGene Summary
Prohibitin is an evolutionarily conserved gene that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations in PHB have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3' untranslated region may function as a trans-acting regulatory RNA. [provided by RefSeq
Other Designations
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Interactome
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Disease
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