Western blot analysis of Lane 1: 293 cell line lysates Lane 2: MCF-7 cell line lysates Lane 3: HepG2 cell line lysates Lane 4: mouse NIH/3T3 cell line lysates Lane 5: rat liver tissue lysates reacted with PHB monoclonal antibody (Cat # MAB12344) at 1:1000 dilution.
Prohibitin is an evolutionarily conserved gene that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations in PHB have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3' untranslated region may function as a trans-acting regulatory RNA. [provided by RefSeq