Western blot analysis of Lane 1: 293T cell line lysates Lane 2: NCI-H1299 cell line lysates Lane 3: rat PC-12 cell line lysates reacted with UCHL1 monoclonal antibody (Cat # MAB12336) at 1:1000 dilution.
The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease