Western blot analysis of Lane 1: 293 cell line lysates Lane 2: CEM cell line lysates Lane 3: HepG2 cell line lysates Lane 4: Jurkat cell line lysates Lane 5: Hela cell line lysates Lane 6: Raji cell line lysates reacted with H2AFX monoclonal antibody (Cat # MAB12332) at 1:2000 dilution.
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq