H2AFX monoclonal antibody, clone 938CT5.1.1
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Specification
Product Description
Mouse monoclonal antibody raised against synthetic peptide of human H2AFX.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to amino acids 115-143 at C-terminus region of human H2AFX.
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Isotype
IgG1
Recommend Usage
Immunohistochemistry (1:25)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of Lane 1: 293 cell line lysates Lane 2: CEM cell line lysates Lane 3: HepG2 cell line lysates Lane 4: Jurkat cell line lysates Lane 5: Hela cell line lysates Lane 6: Raji cell line lysates reacted with H2AFX monoclonal antibody (Cat # MAB12332) at 1:2000 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of paraffin-embedded human prostate section reacted with H2AFX monoclonal antibody (Cat # MAB12332) at 1:25 dilution. -
Gene Info — H2AFX
Entrez GeneID
3014Gene Name
H2AFX
Gene Alias
H2A.X, H2A/X, H2AX
Gene Description
H2A histone family, member X
Omim ID
601772Gene Ontology
HyperlinkGene Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq
Other Designations
H2AX histone
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Interactome
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