Western blot analysis of Lane 1: U266 cell line lysates Lane 2: mouse Neuro-2a whole cell lysates Lane 3: rat PC-12 whole cell lysates Lane 4: C6 cell line lysates Lane 5: mouse brain tissue lysates reacted with UCHL1 monoclonal antibody (Cat # MAB12315) at 1:1000 dilution.
The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease