MAP4K3 monoclonal antibody, clone 219CT8.3.1
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of MCF-7 cell line lysates reacted with MAP4K3 monoclonal antibody (Cat # MAB12312) at 1:1000 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of formalin-fixed and paraffin-embedded human skeletal muscle section reacted with MAP4K3 monoclonal antibody (Cat # MAB12312) at 1:100 dilution.
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Specification
Product Description
Mouse monoclonal antibody raised against human MAP4K3.
Immunogen
Recombinant protein corresponding to human MAP4K3.
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Euglobulin precipitation
Isotype
IgM, kappa
Recommend Usage
Immunohistochemistry (1:100)
Western Blot (1:100-1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of MCF-7 cell line lysates reacted with MAP4K3 monoclonal antibody (Cat # MAB12312) at 1:1000 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of formalin-fixed and paraffin-embedded human skeletal muscle section reacted with MAP4K3 monoclonal antibody (Cat # MAB12312) at 1:100 dilution. -
Gene Info — MAP4K3
Entrez GeneID
8491Gene Name
MAP4K3
Gene Alias
GLK, MAPKKKK3, RAB8IPL1
Gene Description
mitogen-activated protein kinase kinase kinase kinase 3
Omim ID
604921Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the Ste20 family of serine/threonine protein kinases. The protein belongs to the subfamily that consists of members, such as germinal center kinase (GCK), that are characterized by an N-terminal catalytic domain and C-terminal regulatory domain. The kinase activity of the encoded protein can be stimulated by UV radiation and tumor necrosis factor-alpha. The protein specifically activates the c-Jun N-terminal kinase (JNK) signaling pathway. Evidence suggests that it functions upstream of mitogen-activated protein kinase kinase kinase 1 (MEKK1). This gene previously was referred to as RAB8-interacting protein-like 1 (RAB8IPL1), but it has been renamed mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3). [provided by RefSeq
Other Designations
germinal center kinase-like kinase|germinal center kinase-related protein kinase
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Interactome
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Pathway
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Disease
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