MMP2 monoclonal antibody, clone 6E3F8
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of T47D cell line lysates reacted with MMP2 monoclonal antibody (Cat # MAB12299) at 1:200 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of formalin-fixed and paraffin-embedded human lung carcinoma reacted with MMP2 monoclonal antibody (Cat # MAB12299) at 1:50-1:100 dilution.
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Specification
Product Description
Mouse monoclonal antibody raised against human MMP2.
Immunogen
Recombinant protein corresponding to human MMP2.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG2b, kappa
Recommend Usage
Immunohistochemistry (1:50-1:100)
Western Blot (1:200-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In ascites (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of T47D cell line lysates reacted with MMP2 monoclonal antibody (Cat # MAB12299) at 1:200 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of formalin-fixed and paraffin-embedded human lung carcinoma reacted with MMP2 monoclonal antibody (Cat # MAB12299) at 1:50-1:100 dilution. -
Gene Info — MMP2
Entrez GeneID
4313Gene Name
MMP2
Gene Alias
CLG4, CLG4A, MMP-II, MONA, TBE-1
Gene Description
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
Gene Ontology
HyperlinkGene Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
collagenase type IV-A|matrix metalloproteinase 2|matrix metalloproteinase-II|neutrophil gelatinase
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Interactome
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Pathway
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Disease
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