Western blot analysis of Lane 1: mouse brain tissue lysates Lane 2: Y79 whole cell lysates Lane 3: CEM whole cell lysates Lane 4: 293 whole cell lysates reacted with TUBB1 monoclonal antibody (Cat # MAB12274) at 1:100-1:500 dilution.
Microtubules are involved in a wide variety of cellular processes, including mitosis, morphogenesis, platelet formation, and mobility of cilia and flagella. Circulating platelets carry a single marginal microtubule coil that is wound in 8 to 12 turns and is responsible for platelet shape. TUBB1 is the major beta-tubulin expressed in platelets and megakaryocytes and is required for optimal platelet assembly (Wang et al., 1986 [PubMed 3782288]; Schulze et al., 2004 [PubMed 15315966]).[supplied by OMIM