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Last updated: 2017/12/10

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DSG3 monoclonal antibody, clone 6G2C11

  • Catalog # : MAB12254
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against partial recombinant human DSG3.
  • Immunogen:
  • Recombinant protein corresponding to amino acids 55-159 of human DSG3.
  • Host:
  • Mouse
  • Theoretical MW (kDa):
  • 107.5
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Isotype:
  • IgG1
  • Recommend Usage:
  • ELISA (1:10000)
    Flow Cytometry (1:200-1:400)
    Immunohistochemistry (1:200-1:1000)
    Western Blot (1:500-1:2000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.05% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of A431 cell lysate with DSG3 monoclonal antibody, clone 6G2C11 (Cat# MAB12254) at 1:500-1:2000 dilution.
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • Western blot analysis of Lane 1: Negative control [HEK293 cell lysate]; Lane 2: Over-expression lysate [DSG3 (AA: 55-159)-hIgGFc transfected HEK293 cells] with DSG3 monoclonal antibody, clone 6G2C11 (Cat# MAB12254) at 1:500-1:2000 dilution.
  • Western Blot (Recombinant protein)
  • Western Blot (Recombinant protein)
  • Western blot analysis of human DSG3 (AA: 55-159) recombinant protein (Expected MW is 37.5 kDa) with DSG3 monoclonal antibody, clone 6G2C11 (Cat# MAB12254) at 1:500-1:2000 dilution.
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical staining of human esophageal cancer tissues (A) and esophageal tissues (B) with DSG3 monoclonal antibody, clone 6G2C11 (Cat# MAB12254) at 1:200-1:1000 dilution.
  • ELISA
  • ELISA
  • ELISA analysis of DSG3 monoclonal antibody, clone 6G2C11 (Cat# MAB12254) at 1:10000 dilution.
  • Flow Cytometry
  • Flow Cytometry
  • Flow Cytometry analysis of A431 cells with DSG3 monoclonal antibody, clone 6G2C11 (Cat# MAB12254) at 1:200-1:400 dilution (Green) and negative control (Red).
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • enlarge
  • Western Blot (Recombinant protein)
  • Western Blot (Recombinant protein)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 1830
  • Gene Name:
  • DSG3
  • Gene Alias:
  • CDHF6,DKFZp686P23184,PVA
  • Gene Description:
  • desmoglein 3 (pemphigus vulgaris antigen)
  • Gene Summary:
  • Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris. [provided by RefSeq
  • Other Designations:
  • 130-kD pemphigus vulgaris antigen,desmoglein 3,pemphigus vulgaris antigen
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