Western blot analysis of Lane 1: Negative control [HEK293 cell lysate]; Lane 2: Over-expression lysate [MEN1 (AA: 392-554)-hIgGFc transfected HEK293 cells] with MEN1 monoclonal antibody, clone 7D3E10 (Cat# MAB12246) at 1:500-1:2000 dilution.
Western Blot (Recombinant protein)
Western blot analysis of human MEN1 (AA: 392-554) recombinant protein (Expected MW is 43.3 kDa) with MEN1 monoclonal antibody, clone 7D3E10 (Cat# MAB12246) at 1:500-1:2000 dilution.
This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants. [provided by RefSeq