Rat monoclonal antibody raised against mouse Cd44 variant isoform 10-exon 16 (v10-e16).
Mouse Cd44 variant isoform 8-10 transfected cell.
Protein G purification
Flow cytomerty (1-10 ug/mL) Cancer stem cell enrichment The optimal working dilution should be determined by the end user.
Store at 2-8°C. Aliquot to avoid repeated freezing and thawing.
Cancer Stem Cell Enrichment Cancer Stem Cells (CSCs) have been identified as a subset of distinct population in many tumors and can drive cancer relapse and metastasis with their abilities to self-renew and differentiate into various types of cancer cells. Development of therapies specifically and effectively targeting CSCs thus is necessary to improve the survival and quality of life for cancer patients, especially for patients with metastatic diseases. Clone RM1 can be used for enrichment of CSCs with a cell sorter, and further be applied for studying mechanisms by which CSCs cause cancer relapse and metastasis to develop new drugs against CSCs.