NEFH monoclonal antibody, clone SPM563
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Specification
Product Description
Mouse monoclonal antibody raised against NEFH.
Immunogen
Recombinant protein corresponding to human NEFH.
Host
Mouse
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1
Recommend Usage
Immunohistochemistry (0.5-1 ug/mL)
Western blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% BSA, 0.05% sodium azide).
Storage Instruction
Store at 4°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human cerebellum with NEFH monoclonal antibody, clone SPM563 (Cat # MAB12119). -
Gene Info — NEFH
Entrez GeneID
4744Protein Accession#
P12036Gene Name
NEFH
Gene Alias
NFH
Gene Description
neurofilament, heavy polypeptide
Gene Ontology
HyperlinkGene Summary
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. [provided by RefSeq
Other Designations
neurofilament triplet H protein|neurofilament, heavy polypeptide 200kDa
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Interactome
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Pathway
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Disease
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