Western blot analysis of UCHL1 in Lane 1: Human brain lysate Lane 2: Mouse brain lysate Lane 3: Rat brain lysate with UCHL1 monoclonal antibody, clone SPM574 (Cat# MAB12063).
The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease