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DUX4 monoclonal antibody, clone P2B1 (PE/ATTO 594)

  • Catalog # : MAB11456
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against recombinant partial DUX4.
  • Immunogen:
  • Recombinant GST fusion protein corresponding to a 76 amino acid fragment at C-terminus of human DUX4.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • This antibody recognizes human DUX4. It does not cross-react with DUX4c.
  • Form:
  • Liquid
  • Conjugation:
  • PE/ATTO 594
  • Purification:
  • Protein G purification
  • Isotype:
  • IgG1
  • Recommend Usage:
  • Western Blot (1:1000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4 (50% glycerol, 0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • Application Data with Unconjugated Antibody
  • Immunofluorescence

    Immunofluorescent staining of C2C12 cells transfected pCS2+DUX4 with DUX4 monoclonal antibody, clone P2B1 (Cat # MAB11442) at 10 ug/mL (left).
    Counter-stained with DAPI for nuclei (right).

    Western Blot (Transfected lysate)

    Western blot analysis of C2C12 cells transfected with pCS2+DUX4 which contains an additional upstream start site with DUX4 monoclonal antibody, clone P2B1 (Cat # MAB11442).

  • Excitation (Max):
  • 535 nm
  • Emission (Max):
  • 627 nm
  • Applications
  • Western Blot (Transfected lysate)
  • Immunohistochemistry
  • Immunofluorescence
  • Application Image
  • Western Blot (Transfected lysate)
  • Immunohistochemistry
  • Immunofluorescence
  • Gene Information
  • Gene Name:
  • DUX4
  • Gene Alias:
  • DUX10
  • Gene Description:
  • double homeobox, 4
  • Gene Summary:
  • This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that contains two homeoboxes; the repeat-array and ORF is conserved in other mammals. There was no evidence for transcription from standard cDNA libraries however RTPCR and in-vitro expression experiments indicate that the ORF is transcribed and the encoded protein has been reported to function as a transcriptional activator of paired-like homeodomain transcription factor 1 (PITX1; GeneID 5307). Contraction of the microsatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). [provided by RefSeq
  • Other Designations:
  • double homeobox protein 4,double homeobox protein DUX10
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