IKBKG monoclonal antibody, clone 55AT986.5.78
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant IKBKG.
Immunogen
Recombinant His fusion protein corresponding to full length human IKBKG.
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Isotype
IgG1
Recommend Usage
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
The IKBKG monoclonal antibody, clone 55AT986.5.78 (Cat # MAB1141) is used in Western blot to detect IKBKG in ZR-75-1 cell lysate -
Gene Info — IKBKG
Entrez GeneID
8517Protein Accession#
NP_003630;Q9Y6K9Gene Name
IKBKG
Gene Alias
AMCBX1, FIP-3, FIP3, Fip3p, IKK-gamma, IP, IP1, IP2, IPD2, NEMO
Gene Description
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
Gene Ontology
HyperlinkGene Summary
This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [supplied by RefSeq
Other Designations
NFkappaB essential modulator|OTTHUMP00000026027|OTTHUMP00000026028|OTTHUMP00000026029|incontinentia pigmenti
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Interactome
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Pathway
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Disease
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Publication Reference
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Immune deficiency caused by impaired expression of nuclear factor-kappaB essential modifier (NEMO) because of a mutation in the 5' untranslated region of the NEMO gene.
Mooster JL, Cancrini C, Simonetti A, Rossi P, Di Matteo G, Romiti ML, Di Cesare S, Notarangelo L, Geha RS, McDonald DR.
The Journal of Allergy and Clinical Immunology 2010 Jun; 126(1):127.
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The LCR at the IKBKG locus is prone to recombine.
Fusco F, D'Urso M, Miano MG, Ursini MV.
American Journal of Human Genetics 2010 Apr; 86(4):650.
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NEMO gene mutations in Chinese patients with incontinentia pigmenti.
Hsiao PF, Lin SP, Chiang SS, Wu YH, Chen HC, Lin YC.
Journal of the Formosan Medical Association 2010 Mar; 109(3):192.
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Immune deficiency caused by impaired expression of nuclear factor-kappaB essential modifier (NEMO) because of a mutation in the 5' untranslated region of the NEMO gene.
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