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GAB1 monoclonal antibody, clone 1AT1979

  • Catalog # : MAB1139
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against full length recombinant GAB1.
  • Immunogen:
  • Recombinant GST fusion protein corresponding to full length human GAB1.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Protein G purification
  • Isotype:
  • IgG1
  • Recommend Usage:
  • Western Blot (1:1000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot
  • Western Blot
  • Rescue of the JNK pathway by expression of wild-type GAB1 in GAB1-/- cells. GAB1-/- cells were transiently transfected with 1, 2, or 4 ug of the expression construct for human GAB1 cDNA, using the GenePORTER 2 transfection reagent (Gene Therapy Systems Inc.). After incubation, the cells were irradiated with UV-B light at 400 J/m2 or left untreated. Exogenous expression of GAB1 in transfected cells was confirmed by anti-GAB1 immunoblot analysis with wild-type cells as positive control. +/+, wild-type cells; -/-, GAB1-/- cells. (Mol. Cell. Biol. 2004 Feb 15;24 (4) :1531-1539)
  • Immunoprecipitation
  • Immunoprecipitation
  • Wild-type (+/+) and Gab1-/- (-/-) cells were heat shocked (HS) at 42 °C for 1 h or irradiated with UV-B light (400 J/m2) and then incubated at 37°C for 1 h. Cell lysates were prepared and subjected to immunoprecipitation (IP) with an anti-JNK2 antibody. The immunoprecipitates were resolved by SDS- PAGE and immunoblotted (IB) with GAB1 monoclonal antibody, clone 1AT1979 (Cat # MAB1139) . Data courtesy of Dr. GS Feng at The Burnham Institute.
  • Application Image
  • Gene Information
  • Entrez GeneID:
  • 2549
  • Protein Accession#:
  • NP_997006;Q13480
  • Gene Name:
  • GAB1
  • Gene Alias:
  • -
  • Gene Description:
  • GRB2-associated binding protein 1
  • Gene Summary:
  • The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • -
  • Interactome
  • Interactome
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