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Last updated: 2018/1/14
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KIR2DL3 monoclonal antibody, clone 190IIC311

  • Catalog # : MAB1134
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against partial recombinant KIR2DL3.
  • Immunogen:
  • Recombinant protein corresponding to amino acids 22-245 of human KIR2DL3.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Isotype:
  • IgG2a, kappa
  • Recommend Usage:
  • Flow Cytometry (5-10 ug/106)
    ELISA (1:1000)
    Western Blot (1 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4 (0.09% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • KIR2DL3 monoclonal antibody, clone 190IIC311. Western blot analysis of KIR2DL3 expression in Jurkat.
  • PDF DownloadProtocol Download
  • Flow Cytometry
  • Flow Cytometry
  • Profile of natural killer (NK) cells analyzed by flow cytometry.
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 3804
  • Gene Name:
  • KIR2DL3
  • Gene Alias:
  • CD158B2,CD158b,GL183,KIR-023GB,KIR-K7b,KIR-K7c,KIRCL23,MGC129943,NKAT,NKAT2,NKAT2A,NKAT2B,p58
  • Gene Description:
  • killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
  • Gene Summary:
  • Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq
  • Other Designations:
  • NK-receptor,killer cell immunoglobulin-like receptor 2DL3,natural killer associated transcript 2,natural killer cell inhibitory receptor KIR2DL3,p58 natural killer cell receptor,p58.2 MHC class-I specific NK receptor
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