KIR2DL3 monoclonal antibody, clone 190IIC311
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More Files
- More Functions
Western Blot (Recombinant protein)
Western blot analysis of KIR2DL3 recombinant protein.
Immunocytochemistry
Immunocytochemistry analysis of HeLa cells. The cell was stained with KIR2DL3 monoclonal antibody, clone 190IIC311 (1:100). The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue).
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant KIR2DL3.
Immunogen
Recombinant protein corresponding to amino acids 19-161 of human KIR2DL3.
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Protein G affinity chromatography
Isotype
IgG2a, kappa
Recommend Usage
ELISA
Immunocytochemistry (1:100)
Immunofluorescence (1:100)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (10% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Recombinant protein)
Western blot analysis of KIR2DL3 recombinant protein.Immunocytochemistry
Immunocytochemistry analysis of HeLa cells. The cell was stained with KIR2DL3 monoclonal antibody, clone 190IIC311 (1:100). The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue).Immunofluorescence
Enzyme-linked Immunoabsorbent Assay
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Gene Info — KIR2DL3
Entrez GeneID
3804GeneBank Accession#
NM_014511Protein Accession#
P43628Gene Name
KIR2DL3
Gene Alias
CD158B2, CD158b, GL183, KIR-023GB, KIR-K7b, KIR-K7c, KIRCL23, MGC129943, NKAT, NKAT2, NKAT2A, NKAT2B, p58
Gene Description
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
Omim ID
604938Gene Ontology
HyperlinkGene Summary
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq
Other Designations
NK-receptor|killer cell immunoglobulin-like receptor 2DL3|natural killer associated transcript 2|natural killer cell inhibitory receptor KIR2DL3|p58 natural killer cell receptor|p58.2 MHC class-I specific NK receptor
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Interactome
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Pathway
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Disease
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