CD35 monoclonal antibody, clone E11
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) analysis of human tonsil with CD35 monoclonal antibody, clone E11 (Cat # MAB11296) at 1:200 using peroxidase-conjugate and DAB chromogen (Note: membrane staining).
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Specification
Product Description
Mouse monoclonal antibody raised against CD35 (CR1).
Immunogen
Intact human monocytes (Hogg et al, 1984).
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Isotype
IgG1, kappa
Recommend Usage
Western Blot (1:100-1:2000)
Flow Cytometry (1:10-1:1000)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:200-1:400)
Immunoprecipitation (1:10-1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% BSA, 0.05% sodium azide)
Storage Instruction
Store at 4°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) analysis of human tonsil with CD35 monoclonal antibody, clone E11 (Cat # MAB11296) at 1:200 using peroxidase-conjugate and DAB chromogen (Note: membrane staining).Flow Cytometry
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Gene Info — CR1
Entrez GeneID
1378Gene Name
CR1
Gene Alias
C3BR, CD35, KN
Gene Description
complement component (3b/4b) receptor 1 (Knops blood group)
Gene Ontology
HyperlinkGene Summary
This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq
Other Designations
C3-binding protein|C3b/C4b receptor|CD35 antigen|Knops blood group antigen|complement component receptor 1|complement receptor 1
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Interactome
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Pathway
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Disease
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