Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human pancreas with INS monoclonal antibody, clone 2D11-H5 (Cat # MAB11282) at 1:500 using peroxidase-conjugate and DAB chromogen.
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds. Binding of this mature form of insulin to the insulin receptor (INSR) stimulates glucose uptake. A variety of mutant alleles with changes in the coding region have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. [provided by RefSeq