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NRAS (Q61R) monoclonal antibody, clone SP174

  • Catalog # : MAB11217
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against synthetic peptide of NRAS (Q61R).
  • Immunogen:
  • A synthetic peptide corresponding internal region of human NRAS (Q61R).
  • Host:
  • Rabbit
  • Theoretical MW (kDa):
  • 21
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Protein A/G purification
  • Isotype:
  • IgG
  • Recommend Usage:
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:100)
    Western Blot (1:400)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 10 mM PBS, pH 7.6 (1% BSA, 0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of SK-MEL-2 cell lysate with NRAS (Q61R) monoclonal antibody, clone SP174 (Cat # MAB11217).
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-Fixed Paraffin-Embedded Sections) staining of SK-MEL-2 cell with NRAS (Q61R) monoclonal antibody, clone SP174 (Cat # MAB11217).
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 4893
  • Gene Name:
  • NRAS
  • Gene Alias:
  • ALPS4,N-ras,NRAS1
  • Gene Description:
  • neuroblastoma RAS viral (v-ras) oncogene homolog
  • Gene Summary:
  • This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated to a GTP-bound form by a GTPase activating protein and inactivated to a GDP-bound form by a guanine nucleotide-exchange factor. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). [provided by RefSeq
  • Other Designations:
  • N-ras protein part 4,OTTHUMP00000013879,v-ras neuroblastoma RAS viral oncogene homolog
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