IRF7 monoclonal antibody, clone 3D9
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant IRF7.
Immunogen
Recombinant protein corresponding to amino acids 1-150 of human IRF7.
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Isotype
IgG1, kappa
Recommend Usage
ELISA
Western Blot
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (10% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of Jurkat cell lysates.Enzyme-linked Immunoabsorbent Assay
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Gene Info — IRF7
Entrez GeneID
3665GeneBank Accession#
NM_001572Protein Accession#
NP_001563Gene Name
IRF7
Gene Alias
IRF-7H, IRF7A
Gene Description
interferon regulatory factor 7
Omim ID
605047Gene Ontology
HyperlinkGene Summary
IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established. [provided by RefSeq
Other Designations
OTTHUMP00000162886|interferon regulatory factor-7H
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Interactome
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Pathway
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Disease
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Publication Reference
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Regulation of IRF7 through cell type-specific protein stability.
Prakash A, Levy DE.
Biochemical and Biophysical Research Communications 2006 Mar; 342(1):50.
Application:WB, Mouse, MEFs, Thymocytes, Splenocytes.
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IRF-7 is the master regulator of type-I interferon-dependent immune responses.
Honda K, Yanai H, Negishi H, Asagiri M, Sato M, Mizutani T, Shimada N, Ohba Y, Takaoka A, Yoshida N, Taniguchi T.
Nature 2005 Apr; 434(7034):772.
Application:WB-Ce, Mouse, MEFs.
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Analysis of functional domains of interferon regulatory factor 7 and its association with IRF-3.
Au WC, Yeow WS, Pitha PM.
Virology 2001 Feb; 280(2):273.
Application:WB-Tr, Human, 2fTGH cells.
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Regulation of IRF7 through cell type-specific protein stability.
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