KRT8/KRT18 monoclonal antibody, clone CK8+18 207 (FITC)
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More Files
- More Functions
Immunofluorescence (Circulating Tumor Cell)
MCF-7 cells were stained with KRT8/KRT18-FITC labeled monoclonal antibody (Green) and PTPRC-PE labeled monoclonal antibody (Orange). The cell nucleus were counterstained with DAPI (Blue).
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Specification
Product Description
Mouse monoclonal antibody raised against KRT8/KRT18.
Immunogen
Purified human KRT8/KRT18.
Host
Mouse
Theoretical MW (kDa)
52.5, 45
Reactivity
Human
Form
Liquid
Conjugation
FITC
Concentration
0.2 mg/mL
Isotype
IgG1, kappa
Recommend Usage
Immunocytochemistry (1:50-1:100)
Immunohistochemistry (1:50-1:100)
Immunofluorescence (Circulating Tumor Cell) (1:20)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (1% BSA, 0.05% sodium azide)
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry
Immunocytochemistry
Immunofluorescence (Circulating Tumor Cell)
MCF-7 cells were stained with KRT8/KRT18-FITC labeled monoclonal antibody (Green) and PTPRC-PE labeled monoclonal antibody (Orange). The cell nucleus were counterstained with DAPI (Blue). -
Gene Info — KRT8
Entrez GeneID
3856Gene Name
KRT8
Gene Alias
CARD2, CK8, CYK8, K2C8, K8, KO
Gene Description
keratin 8
Gene Ontology
HyperlinkGene Summary
This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. [provided by RefSeq
Other Designations
cytokeratin 8|keratin, type II cytoskeletal 8
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Gene Info — KRT18
Entrez GeneID
3875Gene Name
KRT18
Gene Alias
CYK18, K18
Gene Description
keratin 18
Gene Ontology
HyperlinkGene Summary
KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
Other Designations
cell proliferation-inducing protein 46|cytokeratin 18
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Interactome
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Pathway
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Disease
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