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PSME3 monoclonal antibody

  • Catalog # : MAB11162
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against full length recombinant protein of PSME3.
  • Immunogen:
  • Recombinant protein corresponding to full length human PSME3.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Protein G purification
  • Recommend Usage:
  • ELISA (1:5000-1:20000)
    Western Blot (1:100-1:2000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4 (1% BSA, 50% glycerol, 0.02% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of PSME3 monoclonal antibody (Cat # MAB11162) at 1:1000 dilution.
    Lane 1: HepG2 whole cell lysate 40 ug/lane.
    Lane 2: Jurkat whole cell lysate 40 ug/lane.
    Lane 3: K-562 whole cell lysate 40 ug/lane.
    Predicted band size: 30 KDa. Observed band size: 33 KDa.
  • ELISA
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • ELISA
  • Gene Information
  • Protein Accession#:
  • P61289;NM_005789
  • Gene Name:
  • PSME3
  • Gene Alias:
  • Ki,PA28-gamma,PA28G,REG-GAMMA
  • Gene Description:
  • proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
  • Gene Summary:
  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring. Two transcript variants encoding different isoforms have been identified. [provided by RefSeq
  • Other Designations:
  • 11S regulator complex gamma subunit,Ki antigen,Ki nuclear autoantigen,activator of multicatalytic protease subunit 3,proteasome activator 28-gamma,proteasome activator subunit 3
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