PPM1A monoclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of HeLa whole cell lysate 40 ug/lane with PPM1A monoclonal antibody (Cat # MAB11157) at 1:1000 dilution.
Predicted band size: 42 KDa. Observed band size: 42 KDa
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant protein of PPM1A.
Immunogen
Recombinant protein corresponding to N-terminus of human PPM1A.
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA (1:5000-1:20000)
Western Blot (1:100-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of HeLa whole cell lysate 40 ug/lane with PPM1A monoclonal antibody (Cat # MAB11157) at 1:1000 dilution.
Predicted band size: 42 KDa. Observed band size: 42 KDaEnzyme-linked Immunoabsorbent Assay
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Gene Info — PPM1A
Entrez GeneID
5494Protein Accession#
P35813;NM_177952.1Gene Name
PPM1A
Gene Alias
FLJ42306, MGC9201, PP2C-ALPHA, PP2CA
Gene Description
protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform
Omim ID
606108Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq
Other Designations
protein phosphatase 1A|protein phosphatase 2C alpha isoform
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Interactome
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Pathway
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Disease
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