Western blot analysis of mouse brain tissue lysate 50 ug/lane with MAP2 monoclonal antibody (Cat # MAB11155) at 1:1000 dilution. Predicted band size: 202 KDa. Observed band size: 300 KDa. Additional band size: 130 KDa.
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isforms have been described. [provided by RefSeq