Anti-Bevacizumab monoclonal antibody, clone 2C8-13
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Specification
Product Description
Mouse monoclonal antibody raised against F(ab)2 fragment of Bevacizumab.
Target gene is VEGFA.Immunogen
F(ab)2 fragment of Bevacizumab.
Host
Mouse
Specificity
Bevacizumab. This antibody is able to interfere the binding between Bevacizumab and VEGF.
Form
Liquid
Purification
Protein G purification
Isotype
IgG1
Recommend Usage
ELISA (2 ug/mL for coating)
The optimal working dilution should be determined by the end user.Storage Buffer
In TBS, pH 8.0 (0.09% sodium azide).
Storage Instruction
Store at 4°C for at least 12 months. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
Blocking
Anti-Bevacizumab monoclonal antibody, clone 2C8-13 (Cat # MAB11128) inhibits the interaction of Bevacizumab and its antigen VGEF. -
Gene Info — VEGFA
Entrez GeneID
7422Gene Name
VEGFA
Gene Alias
MGC70609, VEGF, VEGF-A, VPF
Gene Description
vascular endothelial growth factor A
Gene Ontology
HyperlinkGene Summary
This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms. [provided by RefSeq
Other Designations
vascular endothelial growth factor isoform VEGF165|vascular permeability factor
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Interactome
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Pathway
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Disease
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Publication Reference
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Cancer-derived small extracellular vesicles promote angiogenesis by heparin-bound, bevacizumab-insensitive VEGF, independent of vesicle uptake.
Ko SY, Lee W, Kenny HA, Dang LH, Ellis LM, Jonasch E, Lengyel E, Naora H.
Communications Biology 2019 Oct; 2:386.
Application:Incubated, Recombinant protein.
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Anti-Idiotype DNA Aptamer Affinity Purification-High-Temperature Reversed-Phase Liquid Chromatography: A Simple, Accurate, and Selective Bioanalysis of Bevacizumab.
Tomohiro Yamada, Taro Saito, Yutaka Shimizu, Kaori Tsukakoshi, Hideki Hayashi, Hajime Mizuno, Daiki Tsuji, Keisuke Yamamoto, Kunihiko Itoh, Toshimasa Toyo'oka, Kazunori Ikebukuro, Kenichiro Todoroki.
Molecules (Basel, Switzerland) 2019 Feb; 24(5):857.
Application:Func, N/A, DNA Aptamer.
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Antibody drug quantitation in coexistence with anti-drug antibodies on nSMOL bioanalysis.
Iwamoto N, Hamada A, Shimada T.
Analytical Biochemistry 2017 Nov; 540-541:30.
Application:Func, ELISA (Bevacizumab).
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Bioanalysis of bevacizumab and infliximab by high-temperature reversed-phase liquid chromatography with fluorescence detection after immunoaffinity magnetic purification.
Todoroki K, Nakano T, Eda Y, Ohyama K, Hayashi H, Tsuji D, Min JZ, Inoue K, Iwamoto N, Kawakami A, Ueki Y, Itoh K, Toyo'oka T.
Analytica Chimica Acta 2016 Apr; 916:112.
Application:Conjugation, Beads.
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Cancer-derived small extracellular vesicles promote angiogenesis by heparin-bound, bevacizumab-insensitive VEGF, independent of vesicle uptake.
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