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Last updated: 2017/3/19

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PARP1 monoclonal antibody, clone 10H

  • Catalog # : MAB11119
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against PARP1.
  • Immunogen:
  • Poly (ADP-ribose) mixed with methylated bovine serum albumin.
  • Host:
  • Mouse
  • Form:
  • Liquid
  • Purification:
  • Protein A Chromatography
  • Concentration:
  • 1 mg/mL
  • Isotype:
  • IgG3kappa
  • Recommend Usage:
  • The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 20 mM Tris, 150 mM NaCl, pH 7.4 (1% BSA, 0.02% sodium azide)
  • Storage Instruction:
  • Store at -20°C. For long term storage store at -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Immunohistochemistry
  • Immunohistochemistry
  • Immunohistochemical staining of rat liver with PARP1 monoclonal antibody, clone 10H (Cat # MAB11119).
    Rats were injected i.p. with diethylnitrosamine (200 mg/kg), and the livers were removed and rapidly processed 10 hr later, at peak polymer induction (B). Control (A) was untreated liver.
  • Application Image
  • Gene Information
  • Entrez GeneID:
  • 142
  • Gene Name:
  • PARP1
  • Gene Alias:
  • ADPRT,ADPRT1,PARP,PARP-1,PPOL,pADPRT-1
  • Gene Description:
  • poly (ADP-ribose) polymerase 1
  • Gene Summary:
  • This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq
  • Other Designations:
  • ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase),ADP-ribosyltransferase NAD(+),OTTHUMP00000035663,poly (ADP-ribose) polymerase family, member 1,poly(ADP-ribose) polymerase,poly(ADP-ribose) synthetase,poly(ADP-ribosyl)transferase
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