Mouse monoclonal antibody raised against recombinant protein of human MMP2.
Immunogen:
A synthetic peptide corresponding to C-terminus of human MMP2.
Host:
Mouse
Reactivity:
Human
Form:
Liquid
Purification:
Protein A/G purification
Isotype:
IgG1
Recommend Usage:
ELISA Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-5 ug/mL) Western Blot (1-2 ug/mL) The optimal working dilution should be determined by the end user.
Storage Buffer:
In PBS (0.08% sodium azide).
Storage Instruction:
Store at -20°C. Aliquot to avoid repeated freezing and thawing.
Note:
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations:
collagenase type IV-A,matrix metalloproteinase 2,matrix metalloproteinase-II,neutrophil gelatinase