Immunohistochemistry on formalin-fixed paraffin embedded human tonsil tissue with citrate buffer antigen retrieval, using 10 ug/mL of MALT1 monoclonal antibody, clone 50 (Cat # MAB11093) (lane 1) or mouse IgG1 kappa Isotype Control Purified antibody (lane 2) followed by Anti-mouse Ig Biotin and DAB visualization. Nuclei are counterstained with hematoxylin.
This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq