Staining of mouse splenocytes with 0.25 ug hamster IgG Isotype Control Purified (open histogram) or 0.25 ug CD27 monoclonal antibody, clone LG.7F9 (Cat # MAB11068) (filled histogram) followed by Anti-Armenian hamster IgG FITC. Total viable cells were used for analysis.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq